Therapeutic Drug Monitoring of Amiodarone and Desethylamiodarone
نویسندگان
چکیده
منابع مشابه
Liquid-chromatographic determination of amiodarone and N-desethylamiodarone in serum.
We have developed a stable and simple normal-phase liquid-chromatographic method for simultaneously measuring amiodarone and its metabolite, N-desethylamiodarone, within 8 min. The chromatographic system consists of a 15 cm x 3.9 mm Waters "Resolve" silica column and a mobile phase of ammonium sulfate (17 mmol/L, pH 6.8) and methanol (8/92 by vol), pumped at 1.8 mL/min and monitored at 254 nm. ...
متن کاملMechanisms of Amiodarone and Desethylamiodarone Cytotoxicity in Human Lung Cells
Amiodarone (AM) is a potent antidysrhythmic agent which can cause potentially lifethreatening pulmonary fibrosis, and N-desethylamiodarone (DEA) is a metabolite of AM that may contribute to the toxicity of AM in vivo. Recent evidence has implicated the involvement of the renin-angiotensin system (RAS) in the initiation and progression of amiodarone-induced pulmonary toxicity. In cultured HPL1A ...
متن کاملA Review on Therapeutic Drug Monitoring of Immunosuppressant Drugs
Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced ...
متن کاملPhenoconversion and Therapeutic Drug Monitoring
Disclosures of Competing Interests: This letter to the editor was completed without any external funding. 18 No commercial organizations had any role in the writing of this paper for publication. 20 request from the corresponding author) and declares: no financial relationships with any organizations that 21 might have an interest in the submitted work in the previous 3 years.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Therapeutics
سال: 2017
ISSN: 0149-2918
DOI: 10.1016/j.clinthera.2017.05.254